An overwhelming excess of females, providing sexual attention towards an overtly attractive male. This one-to-many ratio results in several unattended females, creating an overflow or “run-off” effect. This pussy run-off is then collected by the inital target’s less attractive male friends and colleagues.
A plug is a person who sells weed or other drugs. To run off on the plug means to run away from a drug dealer, with the product, without paying them the agreed upon amount. This is currently being done as a "fun prank" to video tape and post online, often backfiring and ending in disaster.
"BRO she was riding me, didnt get the towel in time afterwards and I literally CAME in my own ass."
"Damn bro, you were a victim of the Mississippi run-off."
"Sick."