A response to show compassion when your friend starts talking about how terrible his life is, often using extreme examples that no one else could relate to.
Person A: My car broke down, I lost my job, and my dog died all in one week!
Person B: Damn... that's rough, buddy.
to show your compassion and sympathy to someone who is in pain or in when the bring up how horrible there life is.
or
when you want to be sarcastic and funny and bring up "thats rough buddy" among friends who have watched Avatar The Last Airbender.
