1. A query as to one's preference, specifically in regards to consummable goods
2. a query as to one's preference in alcoholic beverage or drugs
3. a question of one's preference in women
1. Alfred: What's your poison?
Rudyard: Give me a slice of pepperoni, beyotch!
2. Alfred: What's your poison?
Rudyard: Give me some mother fuckin' crack!
3. Alfred: What's your posion?
Rudyard: I likes me the big-titty bitches yo!
Alfred: Word!
By Fidelity
Whats Your Poison?
usually said by sleazy guys in bars as a way of asking to buy you a drink
An awesome podcast that talks about anything that makes people uncomfortable. Like awkward sex, brutal crimes, and anything taboo, all while drinking some sort of appropriate alcohol. Booze & Taboos.
-Have you heard the new episode of 'What's Your Poison?'
-No, why?
-She had to explain fisting to her grandmother!