Genetic make-up is when you see someone who has one
astounding feature and nothing else (such as a
great ass but a flat chest and
a butterface.) It's God's way of making it up to a person for screwing them in every other way.
God: "Hey, sorry about the flat chest,
bad skin, and no brains. Here's an amazing ass. It's my
genetic make-up to you."
God: "Yeah, I made you tall, thin, and socially awkward. I'll
make it up to you. Here's a 10 inch crank."