To make oneself to look like the biggest jackass in the universe, for example, when someone makes a great effort to shut someone down by making themselves seem very smart.
The act of, in a massive burst of rage, gain unnatural abilities and utterly destroy the person or object that is annoying you.
jim: this computer is really annoying me. stupid windows vista.
george: how about you NULLIFY YOUR OPPONENT!!!
jim: (shoots frickin laser beams out of his eyes, NULLIFYING THE CRAP OUT OF the computer).