Define G Up Hoes Down Meaning

Your boys are first priority.G's up. Hoes are second. Hoes down

Type of Mdma aka Ecstasy popular on the east coast (especially Georgia and south Florida.

Its supposed larger dose of mdma causes it to be more expensive than "normal E"

Example prices of a city in south florida:
Regular E: $15 Each
Gs up: $20 Each