Any black person who likes rap music (especially gangsta rap) and/or is part of the black gang youth culture.
It's a pun that utilizes the fact that shizzle can mean "shit" as well as "sure". So while to some "shizzle nizzle" describes somebody who says "for shizzle my nizzle", it actually means "that fuckin idiot of a shit nigger".
certain groups or gangs that can't speak english properly, so they have to make up they're own words in there place you they can say them w/ out screwin up.
Fo' shizzle ma' nizzle" is a bastardization of "fo' sheezy mah neezy" which is a bastardization of "for sure mah nigga" which is a bastardization of "I concur with you whole-heartedly my African American brother"