1) An alternate to 'motherfucker' to the
impersonal; more accurately directed at
inanimate objects and situations, whereas motherfucker is generally reserved for person-to-person
communications.
2) A dire situation or circumstance.
3) Short for 'the mother of all bitches'.
God that test was a MOTHER-BITCH!
Mother-bitch! It's
raining AGAIN.
Hand me the bat, Johnny. I'm going to teach that motherbitch a lesson he'll never forget.