Uttered in only the most painful of situations. Most likely stated while the brain is trying to grasp what the fuck just happened to you.
Random Bystander:(gets hit in the face with a baseball traveling 200 miles per hour) THWAK! OUCH! SON OF A FUCK YOU! What the fuck just happened to me? Was I hit by a baseball or just received a roundhouse kick from Chuck Norris?!
This goes beyond son of a bitch or calling someone a whore, this shows that you are really pissed and won't take it anymore, used for both men or women with this one.
your boss writes emails behind your back about your production, "son of a fucking whore bitch!"
you get in trouble at school, and when you get home, your dad yells "son of a fucking whore bitch" cause he knows you're the milk mans