To Annoy, Provoke, or Piss someone Off. Most dumbfucks seem to think this originates from a family guy movie, but the TRUTH is that it's been used for decades, and in popular media actually orginates from a movie called PLANES, TRAINS, and AUTOMOBILES, a classic comedy. Quote: "Del: Don't let me stand in your way, please don't let me stand in your way. The last thing I want to be remembered as is an annoying blabbermouth... You know, nothing grinds my gears worse than some chowderhead that doesn't know when to keep his big trap shut... If you catch me running off with my mouth, just give me a poke on the chubbs... "
A phrase that is a parody of Peter Griffin's infamous quote.
It is typically used with video game related frustrations. If you use it with non-video game related stuff then you sound weird.