Dysphoria is an experience trans,
genderqueer, and non-binary people have. It describes discomfort, loathing, anxiety, and depression revolving around one's social gender role and/or physical sex characteristics. It's a very serious experience that leads to larger anxiety/depression problems,
depersonalization, thoughts of suicide, social withdrawal, self harm, etc.
Fallon: Where were you last night? We missed you at the party.
Skylar: Sorry. I had a serious bout of dysphoria and couldn't bring myself to go.
Fallon: Oh,
I understand. You didn't miss much, anyway.