Define What Is Up With That Meaning

The way you greet a friend when you are feeling a little bit retro and a little bit geeky.

Asks what another has his attention on. What is he thinking about or busy with? "Up" in this case is using a slang definition from around the 1930s meaning: occupied with, busy with.

This question is often used to start conversations with.

What you say when you do not really know what to say.

What's new; What's going on? wussup

The question often asked, when a foulness beyond belief emanates from where the sun don't shine.

This is a combination of "what's goin on?" and "what's up?". I said this accidently the first time I talked to this guy on the phone. I was trying to be cool and confident but inside I was nervous as hell! LOL

What me up means, you asked someone to update or brief you about the current affairs or relevant local or global affairs.

to be muttered directly after a sweet comeback.

Whats up with me and you. When are you gonna let me get some.

Phrase often used by those alien to slang.