Stuck up and
snobby; arrogant. Someone who has jumped so far
up their own ass, though not necessarily a male, that they become intolerable. Inspired by ponytails: People who wear / have them tend to act better than others.
"That girl is so
up dude."
"Your boyfriend is hot but he's is
too too fucking up dude."
"Man, chill out, don't be so up dude!"